May 4, 2025
EP. 340 — Christina Applegate and Jamie-Lynn Sigler
Jamie-Lynn Sigler feels giddy about being Conan O’Brien’s friend. Christina Applegate feels awesome about being Conan O’Brien’s friend.
Jamie-Lynn and Christina sit down with Conan to discuss their respective MS diagnoses, exploring growth and self-reflection on their podcast MeSsy, and why it’s so important to get specific about your vulnerability. Later, Matt Gourley reveals his family’s eerily accurate Oscars fashion predictions.
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Recent Episodes
See AllAugust 31, 2025
EP. 359 — Chris Fleming
Guest Chris Fleming
Comedian Chris Fleming feels in the constant threat of physical danger about being Conan O’Brien’s friend.
August 27, 2025
Conan and the Chill Chums revel in a season of success and check out Aaron Bleyaert’s newest weapon on the Summer S’mores finale.
August 24, 2025
EP. 358 — Greg Daniels
Guest Greg Daniels
Writer, showrunner, and producer Greg Daniels feels outraged about being Conan O’Brien’s friend.