EP. 340 — Christina Applegate and Jamie-Lynn Sigler

Jamie-Lynn Sigler feels giddy about being Conan O’Brien’s friend. Christina Applegate feels awesome about being Conan O’Brien’s friend.

Jamie-Lynn and Christina sit down with Conan to discuss their respective MS diagnoses, exploring growth and self-reflection on their podcast MeSsy, and why it’s so important to get specific about your vulnerability. Later, Matt Gourley reveals his family’s eerily accurate Oscars fashion predictions.

For Conan videos, tour dates and more visit TeamCoco.com.

Got a question for Conan? Call our voicemail: (669) 587-2847.

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EP. 10258 — Summer S’mores with Conan and the Chill Chums Season 5 Episode 6

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August 24, 2025

EP. 358 — Greg Daniels

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