May 4, 2025

EP. 340 — Christina Applegate and Jamie-Lynn Sigler

Jamie-Lynn Sigler feels giddy about being Conan O’Brien’s friend. Christina Applegate feels awesome about being Conan O’Brien’s friend.

Jamie-Lynn and Christina sit down with Conan to discuss their respective MS diagnoses, exploring growth and self-reflection on their podcast MeSsy, and why it’s so important to get specific about your vulnerability. Later, Matt Gourley reveals his family’s eerily accurate Oscars fashion predictions.

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April 27, 2025

EP. 339 — Bill Hader Returns Again

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Actor, comedian, and director Bill Hader feels grateful about being Conan O’Brien’s friend.

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April 23, 2025

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