Actress Kaley Cuoco returns to chat with Conan once again about shooting her action movie Role Play while pregnant, being discouraged from acting as a child, and her new line of eco-friendly dog products Oh Norman!

Conan chats with Jonah from Tupelo, MS about selling used cars, tattoos, and Conan’s go-to universal sales pitch.

Musician John Mayer feels accepted about being Conan O’Brien’s friend.

Conan talks to Patti from Austin, TX about working as the art director for a slime company, turning 30, and internet slime girls.

Actress Natasha Lyonne, a totally normal person, feels blank about being Conan O’Brien’s friend.

Conan chats with Katie from Massachusetts about her job as a social worker for a kidney transplant list, her Conan made out of Legos, and what characteristics Conan would pass down via organ transplant.

Actress and comedian Niecy Nash Betts feels very sexy about being Conan O’Brien’s friend.

Conan chats with Tom from Dublin about reclaiming Bram Stoker as an Irish icon and  what events Conan would suggest for the annual Bram Stoker festival.

Conan chats with Sean from Halifax about the strangest things he’s found while diving and his rivalry with a local snapping turtle.

Writer and director Jordan Peele feels honored, absolutely honored about being Conan O’Brien’s friend.

When one of their own mysteriously disappears, Conan and the Chill Chums are forced to put their detective skills to the test. Welcome to… The Hoppining!

Comedian Gary Gulman feels ecstatic about being Conan O’Brien’s friend.

Conan talks to Logan from Tulsa, Oklahoma about working as a reconstructive urologist, the operating room playlist, and getting up at night to go pee.

President Joe Biden feels lucky to be Conan O’Brien’s friend.